The basic rules of playing the game, creating a character, using skills, resolving combat etc. have been written genre-independent, so you should be able to use them as they are in almost any type of game setting, be it high fantasy or science fiction.
Some aspects of the game are intended for a modern setting, like the names and pictures of different roles. However, the contents of each role are archetypical and as such will fit other settings with very little or no modification – in some cases all you need to do is change the name.
The equipment card decks are very genre-specific. If you want to play a fantasy or science fiction game, you need different equipment cards. You can modify the existing cards or create your own using the Magic Set Editor program.